abstract:CONTEXT:Thonningianin A is an ellagitannin substance and displays multiple pharmacological activities. OBJECTIVE:This study investigated the pharmacokinetic characteristics of thonningianin A after oral administration in rats using a fully validated liquid chromatography tandem mass spectrometry (LC-MS/MS) method. MA...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1913188
更新日期:2021-12-01 00:00:00
abstract::This study aimed to investigate the implication of REDD1 on airborne particle matter-induced lung injury and whether it is mediated through autophagy. Cell viability in BEAS-2B cells induced by PM2.5 was measured by CCK-8. RT-qPCR and Western blot were performed to determine mRNA and protein levels of REDD1 as well as...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1917227
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:In low-resource public schools, these costs may be amplified for early career teachers who help students bear increasingly complex burdens despite lack of resources and specialized support. However, there are limited studies on how care work and its costs are experienced by early-career Filipino public school t...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1917881
更新日期:2021-12-01 00:00:00
abstract::There is limited information on contraceptive values and preferences of sex workers. We conducted a mixed-method study to explore contraceptive values and preferences among sex workers. We conducted an online survey with individuals from 38 countries (n = 239), 6 focus group discussions (FGD, n = 68) in Zimbabwe, and ...
journal_title:Sexual and reproductive health matterspub_type: 杂志文章
doi:10.1080/26410397.2021.1913787
更新日期:2021-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a leading cause of mortality in cancer patients, but the association between miR-125b-2-3p and the onset and prognosis of HCC has not been reported in previous studies; thus, the clinicopathological implications of miR-125b-2-3p in HCC require elaboration. To examine the expression of...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1921549
更新日期:2021-12-01 00:00:00
abstract::Bladder cancer is one of the most common malignant tumors worldwide. Accordingly, its incidence and mortality are high. One of the characteristics of cancer is genomic instability. New studies suggest that long non-coding RNAs (lncRNAs) play an important role in maintaining genomic instability. This study aimed to ide...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1924555
更新日期:2021-12-01 00:00:00
abstract::People Living with HIV/AIDS (PLWHA's) quality of life (QoL) is determined by the lifetime treatment sustainability. Republic of Indonesia Minister of Health's Decree Number 328 of 2003 stated that government subsidies the PLWHA's medication and treatment, despite not covering entire medication and treatment cost. The ...
journal_title:SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliancepub_type: 杂志文章
doi:10.1080/17290376.2020.1858946
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The conventional method of implanting balloon-expandable SAPIEN-3 (S3) valve results in a final 70:30 or 80:20 ratio of the valve in the aorta:left ventricular outflow tract with published rates of permanent pacemaker around 10%. We sought to evaluate whether higher implantation of S3 reduces conduction abno...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1851044
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The conventional method of implanting balloon-expandable SAPIEN-3 (S3) valve results in a final 70:30 or 80:20 ratio of the valve in the aorta:left ventricular outflow tract with published rates of permanent pacemaker around 10%. We sought to evaluate whether higher implantation of S3 reduces conduction abno...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1867323
更新日期:2021-12-01 00:00:00
abstract::Tribendimidine has been successful in treating hookworm infections and may serve as an alternative to albendazole should resistance arise. Our aims were to (i) characterize the pharmacokinetics (PK) of tribendimidine's primary metabolite, deacetylated amidantel (dADT), and secondary metabolite, acetylated derivative o...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1840620
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Canadian Surgical Foundations (SF) residency programs transitioned to competency-based medical education in 2018. It is unknown how well the SF curriculum prepares surgery residents to recognize and manage common perioperative patient presentations. We sought to evaluate the national SF curriculum using the ...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1828617
更新日期:2021-12-01 00:00:00
abstract::Background: Health characteristics associated with uric acid (UA) in the Roma minority remain less well known. The study sought to determine the ethnicity- and sex-specific associations of serum UA with health factors in Eastern Slovakian Roma and non-Roma populations. Methods: Data from the comparative cross-sectiona...
journal_title:Annals of medicinepub_type: 杂志文章,评审
doi:10.1080/07853890.2020.1839959
更新日期:2021-12-01 00:00:00
abstract::This review on atypical angucyclinones possessing an aromatic cleavage of the C-ring covers literature between 1995 and early 2020.The unusual framework of the middle C-ring, "broken" as a result of biotransformations and oxidations in vivo and bearing an sp3-C connection, is of interest for biosynthetic investigation...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1871919
更新日期:2021-12-01 00:00:00
abstract::The Publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/with...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2020.1867439
更新日期:2021-12-01 00:00:00
abstract::Tigecycline is an alternative antibiotic for managing carbapenem-resistant Gram-negative bacterial infections. However, disk diffusion and automated testing often show false-intermediate or false-resistant results in tigecycline susceptibility, misleading clinical antimicrobial therapy. Broth microdilution (BMD) is th...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2020.1858100
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:Clear cell meningioma (CCM) is a rare WHO grade II meningioma variant, characterized by aggressive features and a high tumor recurrence rate. In this study, we compared overall and progression-free survivals between CCMs and other WHO grade II meningiomas. METHODS:A retrospective institutional database review ...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2020.1864402
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:There is limited information about the clinical characteristics, treatment and outcome of maintenance hemodialysis patients with COVID-19. Moreover, regional differences are also conceivable since the extend and severity of outbreaks varied among countries. METHODS:In this retrospective, observational, sing...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2020.1853571
更新日期:2021-12-01 00:00:00
abstract::The aim of this study was to evaluate the success of the all-inside repair technique for medial bucket-handle meniscus tear (BHMT) and the factors affecting healing. A total of 36 patients with BHMT who were operated between 2012 and 2018 and completed final follow-up examinations were included in the study. Functiona...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1875664
更新日期:2021-12-01 00:00:00
abstract::The aim of this study was to evaluate the success of the all-inside repair technique for medial bucket-handle meniscus tear (BHMT) and the factors affecting healing. A total of 36 patients with BHMT who were operated between 2012 and 2018 and completed final follow-up examinations were included in the study. Functiona...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1876440
更新日期:2021-12-01 00:00:00
abstract::The aim of this study was to evaluate the success of the all-inside repair technique for medial bucket-handle meniscus tear (BHMT) and the factors affecting healing. A total of 36 patients with BHMT who were operated between 2012 and 2018 and completed final follow-up examinations were included in the study. Functiona...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1874946
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:In December 2017, the World Health Organization (WHO) prequalified the first typhoid conjugate vaccine (TCV) (Typbar-TCV). While no safety concerns were identified in pre- and post-licensure studies, WHO's Global Advisory Committee on Vaccine Safety recommended robust safety evaluation with large-scale TCV i...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1876182
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:In December 2017, the World Health Organization (WHO) prequalified the first typhoid conjugate vaccine (TCV) (Typbar-TCV). While no safety concerns were identified in pre- and post-licensure studies, WHO's Global Advisory Committee on Vaccine Safety recommended robust safety evaluation with large-scale TCV i...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1872741
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:Cytotoxic T-lymphocyte antigen 4 (CTLA-4) polymorphisms at positions of +49 and CT60 in donors have been reported to influence clinical outcome following allogeneic hematopoietic stem cell transplantation (allo-HSCT), such as overall survival (OS), disease free survival (DFS), relapse and the risk of graft ve...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1852762
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Professional soccer players who have sustained a lower limb injury are up to 3× more likely to suffer a reinjury, often of increased severity. Previous injury has been shown to induce compensatory strategies during neuromuscular screening tests, which might mask deficits and lead to misinterpretation of readine...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1876686
更新日期:2021-12-01 00:00:00
abstract::The generalized tonic seizures that occur in myelin-deficient rats can be eliminated temporarily by spinal cord injury or spinal anesthesia. These observations imply that the seizures in this mutant can be triggered by activity in the spinal cord. The results are consistent with an earlier proposal that axons in myeli...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1872905
更新日期:2021-12-01 00:00:00
abstract::The generalized tonic seizures that occur in myelin-deficient rats can be eliminated temporarily by spinal cord injury or spinal anesthesia. These observations imply that the seizures in this mutant can be triggered by activity in the spinal cord. The results are consistent with an earlier proposal that axons in myeli...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1872739
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:To examine the direct and indirect effects of age, APOE ϵ4 genotype, amyloid positivity, and volumetric reductions in AD-prone brain regions as it relates to semantic intrusion errors reflecting proactive semantic interference (PSI) and the failure to recover from proactive semantic interference (frPSI) on th...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2020.1862481
更新日期:2021-12-01 00:00:00
abstract::Intensified travel activities of humans and the ever growing global trade create opportunities of arthropod-borne disease agents and their vectors, such as mosquitoes, to establish in new regions. To update the knowledge of mosquito occurrence and distribution, a national mosquito monitoring programme was initiated in...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1870321
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:Sleep problems and menopausal symptoms are both common complaints among midlife women. However, the associations of the quality and quantity of sleep problems with the severity of menopausal symptoms have not been well studied. Thus, this study aims to examine the relationships between individual sleep proble...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2020.1865993
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Global Health is an emerging field that refers to the health and well-being of the world's population. It is crucial that the next generation of nurses is prepared as global health advocates. There is no prior research of self-assessed global health competencies among nursing faculty in U.S. prelicensure pro...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1872351
更新日期:2021-12-01 00:00:00
abstract::Homogeneous preparations of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase [7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate phosphorylating), EC 4.1.2.15] isolated as the enzyme-phosphoenolpyruvate complex from Escherichia coli are shown by atomic absorption analysis to conta...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1866303
更新日期:2021-12-01 00:00:00
abstract::As a novel type of genetic marker, the microhaplotype has shown promising potential in forensic research. In the present study, we analyzed maternal plasma cell-free DNA (cfDNA) samples from twin pregnancies to validate microhaplotype-based noninvasive prenatal testing (NIPT) for paternity, zygosity, and fetal fractio...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2020.1870413
更新日期:2021-12-01 00:00:00
abstract::As a novel type of genetic marker, the microhaplotype has shown promising potential in forensic research. In the present study, we analyzed maternal plasma cell-free DNA (cfDNA) samples from twin pregnancies to validate microhaplotype-based noninvasive prenatal testing (NIPT) for paternity, zygosity, and fetal fractio...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1865716
更新日期:2021-12-01 00:00:00
abstract::As a novel type of genetic marker, the microhaplotype has shown promising potential in forensic research. In the present study, we analyzed maternal plasma cell-free DNA (cfDNA) samples from twin pregnancies to validate microhaplotype-based noninvasive prenatal testing (NIPT) for paternity, zygosity, and fetal fractio...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2020.1865478
更新日期:2021-12-01 00:00:00
abstract::Recent studies describe in detail the shifts in composition of human-associated polymicrobial communities from health to disease. However, the specific processes that drive the colonization and overgrowth of pathogens within these communities remain incompletely understood. We used in vitro culture systems and a disea...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2020.1861728
更新日期:2021-12-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The increasing national prevalence of diabetes mellitus (DM) and its complications have overstretched the health care system in Tanzania and influenced patients to use herbal medicines as alternative therapeutic strategies. Therefore, an urgent need exists to validate the safety and effic...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1867438
更新日期:2021-12-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The increasing national prevalence of diabetes mellitus (DM) and its complications have overstretched the health care system in Tanzania and influenced patients to use herbal medicines as alternative therapeutic strategies. Therefore, an urgent need exists to validate the safety and effic...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1863958
更新日期:2021-12-01 00:00:00
abstract:Background:We aimed to assess the effectiveness of the health educational booklet intervention in improving parents/guardian's knowledge on prevention of child drowning and, the perception of drowning risk and water safety practice. Methods:A quasi-experimental study was conducted in year 2017 in Selangor, Malaysia am...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1862100
更新日期:2021-12-01 00:00:00
abstract:Background:We aimed to assess the effectiveness of the health educational booklet intervention in improving parents/guardian's knowledge on prevention of child drowning and, the perception of drowning risk and water safety practice. Methods:A quasi-experimental study was conducted in year 2017 in Selangor, Malaysia am...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2020.1856220
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:There is a paucity of data regarding mechanical thrombectomy (MT) in distal arterial occlusions (DAO). We aim to evaluate the safety and efficacy of MT in patients with DAO and compare their outcomes with proximal arterial occlusion (PAO) strokes. METHODS:The Trevo Registry was a prospective open-label MT r...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1858820
更新日期:2021-12-01 00:00:00